VEGFC antibody (AA 101-221) (Biotin)

Catalog No. ABIN5540710

This anti-VEGFC antibody is a Rabbit Polyclonal antibody detecting VEGFC in EIA. Suitable for Human, Mouse and Rat.

Quick Overview for VEGFC antibody (AA 101-221) (Biotin) (ABIN5540710)

Target: VEGFC (Vascular Endothelial Growth Factor C (VEGFC))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This VEGFC antibody is conjugated to Biotin

Application: Enzyme Immunoassay (EIA)

Product Details anti-VEGFC Antibody (Biotin)

Binding Specificity: AA 101-221

Specificity: The unconjugated antibody will react with Rat VEGF-C and will cross-react with Human and Mouse VEGF-C proteins.

Purification: Affinity Chromatography on Protein A

Immunogen: Recombinant Rat VEGF-C native protein (Asp101-Ile221) derived from insect cells (Cat.-No DA3519X)

Isotype: IgG

Application Details

Application Notes: ELISA: 1-5 μg/mL.

Restrictions: For Research Use only

Handling

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store lyophilized at 2-8°C for 6 months or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for VEGFC

Target: VEGFC (Vascular Endothelial Growth Factor C (VEGFC))

Alternative Name: vegf-c,flt4-l

Background: VEGF-C, a member of the VEGF/PDGF family of structurally related proteins, is a potent angiogenic cytokine. It promotes endothelial cell growth, promotes lymphangiogesis, and can also affect vascular permeability. VEGF-C is expressed in various tissues, but is not produced in peripheral blood lymphocytes. It forms cell surfaced-associated non-covalent disulfide linked homodimers, and can bind and activate both VEGFR-2 (flk1) and VEGFR-3 (flt4) receptors. During embryogenesis, VEGF-C may play a role in the formation of the venous and lymphatic vascular systems. Both VEGF-C and VEGF-D are over-expressed in certain cancers, and the resulting elevated levels of VEGF-C or VEGF-D tend to correlate with increased lymphatic metastasis. Recombinant, fully processed rat VEGF-C is a 16-18 kDa non-disulfide linked homodimeric protein consisting of two 116 amino acid polypeptide chains. Due to glycosylation the protein migrates as a 20.0-22.0 kDa band under non-reducing condition.

UniProt: O35757

Pathways: RTK Signaling, Signaling Events mediated by VEGFR1 and VEGFR2