ING2 antibody (AA 1-280)

Catalog No. ABIN5540825

This Mouse Monoclonal antibody specifically detects ING2 in WB and EIA. It exhibits reactivity toward Human.

Quick Overview for ING2 antibody (AA 1-280) (ABIN5540825)

Target: ING2 (Inhibitor of Growth Family, Member 2 (ING2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This ING2 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Clone: AT39E5

Product Details anti-ING2 Antibody

Binding Specificity: AA 1-280

Purification: Protein-A affinity chromatography

Immunogen: Recombinant human ING2 (1-280aa) purified from E. coli

Application Details

Application Notes: The antibody has been tested by ELISA, Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended starting dilution is 1:1000.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS, pH 7.4 containing 0.02 % Sodium Azide and 10 % Glycerol

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for ING2

Target: ING2 (Inhibitor of Growth Family, Member 2 (ING2))

Alternative Name: ing2,ing1l

Background: ING2 is a member of the inhibitor of growth (ING) family. Members of the ING family associate with and modulate the activity of histone acetyltransferase (HAT) and histone deacetylase (HDAC) complexes and function in DNA repair and apoptosis. This protein seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. Also, It is component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. ING2 activity seems to be modulated by binding to phosphoinositides.

UniProt: Q9H160

Pathways: Chromatin Binding, Autophagy, Negative Regulation of intrinsic apoptotic Signaling