alpha 2 Macroglobulin antibody

Catalog No. ABIN5541044

This Mouse Monoclonal antibody specifically detects alpha 2 Macroglobulin in EIA and RIA. It exhibits reactivity toward Human.

Quick Overview for alpha 2 Macroglobulin antibody (ABIN5541044)

Target: alpha 2 Macroglobulin (A2M) (alpha-2-Macroglobulin (A2M))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This alpha 2 Macroglobulin antibody is un-conjugated

Application: Enzyme Immunoassay (EIA), Radioimmunoassay (RIA)

Clone: 2N1-10

Product Details anti-alpha 2 Macroglobulin Antibody

Specificity: This antibody recognises alpha 2-macroglobulin, a tetrameric glycoprotein of 720 kDa which functions as a proteinase inhibitor. Species: Human.

Purification: DEAE-chromatography

Immunogen: Purified alpha-2 macroglobulin from human plasma.

Isotype: IgG1

Application Details

Application Notes: ELISA. Radioimmunoassays

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.09 % Sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for alpha 2 Macroglobulin

Target: alpha 2 Macroglobulin (A2M) (alpha-2-Macroglobulin (A2M))

Alternative Name: alpha-2-macroglobulin,a2m

Background: Alpha 2 macroglobulin is a serum protein which is mainly synthesised in the liver. It functions as a broad range irreversible proteinase inhibitor that forms a trap around most proteases. Alpha 2 macroglobulin is a tetrameric molecule, and with a molecular weight of 720 kDa, it so large a molecule that it tends to remain intravascular. Following conformational change the proteinase is deposited within a central cavity where it is still active but prevented from further contact with its substrate. Removal of the complex is mediated by the generation of recognition sites which react with receptors on a variety of cells including macrophages and liver cells. Alpha 2 macroglobulin is localized on the surface of peripheral blood lymphocytes.

UniProt: P01023

Pathways: Lipid Metabolism