ACE2 antibody (C-Term, Extracellular Domain)

Catalog No. ABIN5541562

The Mouse Monoclonal anti-ACE2 antibody (Clone 11A31) (ABIN5541562) specifically detects ACE2 in WB and IHC (p). The antibody is reactive with Human samples.

Quick Overview for ACE2 antibody (C-Term, Extracellular Domain) (ABIN5541562)

Target: ACE2 (Angiotensin I Converting Enzyme 2 (ACE2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This ACE2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 11A31

Product Details anti-ACE2 Antibody

Binding Specificity: C-Term, Extracellular Domain

Specificity: This antibody was selected for its ability to detect ACE-2. Species: Human.

Purification: Affinity Chromatography on Protein G

Immunogen: Human ACE-2 recombinant protein (extracellular domain).

Isotype: IgG1

Application Details

Application Notes: Western Blot: 1/500-1/1000. Immunohistochemistry on Paraffin Sections: 1/50-1/200.

Restrictions: For Research Use only

Handling

Buffer: Sterile PBS

Storage: 4 °C,-20 °C

Storage Comment: Store lyophilized at 2-8°C for 6 months or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for ACE2

Target: ACE2 (Angiotensin I Converting Enzyme 2 (ACE2))

Alternative Name: ace2

Background: The protein encoded by the gene ACE belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63.

UniProt: Q9BYF1

Pathways: ACE Inhibitor Pathway, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Feeding Behaviour