P-Selectin antibody (Biotin)

Catalog No. ABIN5541729

The Mouse Monoclonal anti-P-Selectin antibody is suitable to detect P-Selectin in samples from Human and Primate. It has been validated for FACS.

Quick Overview for P-Selectin antibody (Biotin) (ABIN5541729)

Target: P-Selectin (SELP) (Selectin P (Granule Membrane Protein 140kDa, Antigen CD62) (SELP))

Reactivity: Human, Primate

Host: Mouse

Clonality: Monoclonal

Conjugate: This P-Selectin antibody is conjugated to Biotin

Application: Flow Cytometry (FACS)

Clone: AK4

Product Details anti-P-Selectin Antibody (Biotin)

Specificity: This antibody recognizes CD62P (P-selectin), a 140 kD single chain type I transmembrane glycoprotein present in secretory alpha-granules in platelets, in Weibel-Palade bodies in endothelial cells and in megakaryocytes it is relocated to the plasma membrane upon activation.

Immunogen: Human platelets

Isotype: IgG1

Application Details

Application Notes: Flow cytometry.

Restrictions: For Research Use only

Handling

Format: Liquid

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store undiluted at 2-8°C. DO NOT FREEZE! Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for P-Selectin

Target: P-Selectin (SELP) (Selectin P (Granule Membrane Protein 140kDa, Antigen CD62) (SELP))

Alternative Name: cd62p,p-selectin

Background: CD62P (P-selectin) is an adhesion glycoprotein that is expressed on platelets and endothelial cells upon their activation. Interaction between CD62P and its mucin-like ligand PSGL-1 (P-selectin glycoprotein ligand-1) expressed on the microvilli of most leukocytes supports leukocyte rolling along postkapillary venules at the earliest time of inflammation. Both CD62P and PSGL-1 are extended glycoproteins that form homodimers. CD62P dimerization is probably mediated through interactions of the transmembrane domains and stabilizes leukocyte tethering and rolling, probably by increasing rebinding within a bond cluster.

UniProt: P16109