GNRH1 antibody (AA 11-60)

Catalog No. ABIN5541891

The Rabbit Polyclonal anti-GNRH1 antibody is suitable to detect GNRH1 in samples from Human, Rat and Mouse. It has been validated for WB and IHC (p).

Quick Overview for GNRH1 antibody (AA 11-60) (ABIN5541891)

Target: GNRH1 (Gonadotropin-Releasing Hormone 1 (Luteinizing-Releasing Hormone) (GNRH1))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GNRH1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-GNRH1 Antibody

Binding Specificity: AA 11-60

Specificity: This antibody detects endogenous levels of GnRH 1 protein.

Purification: Affinity Chromatography using epitope-specific immunogen

Immunogen: Synthetic peptide corresponding to amino acids 11-60 of Human GnRH I.

Application Details

Application Notes: Western blot: 1/500-1/1000. Immunohistochemistry on Paraffin Sections: 1/50-1/200.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 95 % by SDS-PAGE) Aff - Purified

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for GNRH1

Target: GNRH1 (Gonadotropin-Releasing Hormone 1 (Luteinizing-Releasing Hormone) (GNRH1))

Alternative Name: gnrh1,progonadoliberin-1

Background: GnRH is produced by hypothalamic neurons and secreted in a pulsatile manner into the capillary plexus of the median eminence. GnRH affects the release of lutenizing hormone and follicle stimulating hormone from gonadotropic cells in the anterior pituitary. In addition to hypothalamic GnRH (GnRH I), a second GnRH form (GnRH II) functions primarily in the midbrain. GnRH is xpressed in the acrosomal region of human sperm and in the anterior pituitary tissue and cancer cells. Unlike GnRH I, GnRH II is highly expressed outside the brain, particularly in the kidney, bone marrow and prostate, suggesting that it may have multiple functions. GnRH binds to a specific G protein-coupled receptor in the pituitary to regulate synthesis and secretion of gonadotropins.

UniProt: P01148

Pathways: Hormone Activity