TWEAK antibody

Catalog No. ABIN5541911

This Mouse Monoclonal antibody specifically detects TWEAK in FACS and Func. It exhibits reactivity toward Human.

Quick Overview for TWEAK antibody (ABIN5541911)

Target: TWEAK (TNFSF12) (Tumor Necrosis Factor (Ligand) Superfamily, Member 12 (TNFSF12))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TWEAK antibody is un-conjugated

Application: Flow Cytometry (FACS), Functional Studies (Func)

Clone: CARL-1

Product Details anti-TWEAK Antibody

Specificity: This antobody recognizes CD255 / TWEAK, a type II transmembrane protein of the TNF superfamily able to weakly induce apoptosis in many cell types.

Purification: Protein-A affinity chromatography

Immunogen: Human CD255-transfected 2PK-3 cells

Isotype: IgG3

Application Details

Application Notes: Flow cytometry. Functional application: Neutralization.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Phosphate buffered saline (PBS) Preservatives: 15 mM sodium azide, approx. pH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store undiluted at 2-8°C. DO NOT FREEZE! Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for TWEAK

Target: TWEAK (TNFSF12) (Tumor Necrosis Factor (Ligand) Superfamily, Member 12 (TNFSF12))

Alternative Name: tweak,tnfsf12

Background: CD255 / TWEAK (TNF-related weak inducer of apoptosis), a type II transmembrane protein expressed as membrane-bound and secreted form, can induce apoptosis in many tissues and cell lines through its receptor CD266 / TWEAK R. On the other hand, in endothelial cells this interaction can induce proliferation and promote angiogenesis including neovascularization of tumours. CD255 can act in a juxtacrine manner to initiate cellular responses, and induces secretion of pro-inflammatory cytokines. Besides CD266, CD255 may also bind to DR3.

UniProt: O43508

Pathways: Apoptosis