CD36 antibody

Catalog No. ABIN5541988

This anti-CD36 antibody is a Mouse Monoclonal antibody detecting CD36 in FACS, IF, IHC (fro) and ICC. Suitable for Human.

Quick Overview for CD36 antibody (ABIN5541988)

Target: CD36

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD36 antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC)

Clone: 185-1G2

Product Details anti-CD36 Antibody

Specificity: The Monoclonal antibody 185-1G2 recognizes an epitope between amino acids 155-183 on the CD36 Molecule.

Purification: Purified

Immunogen: Derived by fusion of NS1 mouse myeloma cells with spleen cells from BALB/c mice immunized with stimulated Human leucocytes.

Isotype: IgG2a

Application Details

Application Notes: Flow Cytometry: 1/100-1/200. The antibody 185-1G2 can be used for CD36 cell identification, quantification and isolation using flow cytometric methods. Immunocytochemistry. Immunohistochemistry on Frozen Sections. Functional Assay: The antibody has also been reported to bind to a site of CD36 that inhibits CD36 function. Please request a Sodium Azide Free antibody format.

Restrictions: For Research Use only

Handling

Buffer: Buffer System: PBS Preservatives: 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for CD36

Target: CD36

Alternative Name: cd36

Background: The CD36 Molecule is an 88 kDa transmembrane glycoprotein, which is a member of the class B scavenger receptor family of proteins. Alternative names for CD36 include fatty acid translocase (FAT), platelet glycoprotein 4, platelet glycoprotein IIIb and thrombospondin receptor. CD36 is a pattern recognition receptor that is expressed on a wide variety of cells including monocytes, macrophages, platelets, adipocytes, erythrocyte precursors, activated keratinocytes and some endothelial and epithelial cells. Studies suggest that CD36 has multiple cellular functions and binds to a diverse array of ligands including thrombospondin, modified low-density lipoproteins (LDL), anionic phospholipids and long chain fatty acids. As a scavenger receptor, CD36 plays a key role in mediating the uptake of oxidized LDL by macrophages, the formation of foam cells and the development of atherosclerosis. CD36 is also reported to function as negative regulator of angiogenesis, as a cell adhesion molecule involved in platelet adhesion and aggregation, and as a scavenger receptor in the clearance of apoptotic cells and photoreceptor rod outer segments. Furthermore, CD36 is reported to bind toPlasmodium falciparum infected erythrocytes and may play an important role in the pathogenesis of malaria and sickle cell disease.

UniProt: P16671

Pathways: TLR Signaling, Peptide Hormone Metabolism, Response to Growth Hormone Stimulus, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Regulation of Lipid Metabolism by PPARalpha, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Hepatitis C, Toll-Like Receptors Cascades, Lipid Metabolism, S100 Proteins