PARK7/DJ1 antibody

Catalog No. ABIN5542008

The Mouse Monoclonal anti-PARK7/DJ1 antibody is suitable to detect PARK7/DJ1 in samples from Human, Mouse, Rat and Cow. It has been validated for WB, ICC and IF.

Quick Overview for PARK7/DJ1 antibody (ABIN5542008)

Target: PARK7/DJ1 (PARK7) (Parkinson Protein 7 (PARK7))

Reactivity: Human, Mouse, Rat, Cow

Host: Mouse

Clonality: Monoclonal

Conjugate: This PARK7/DJ1 antibody is un-conjugated

Application: Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)

Clone: 4H4

Product Details anti-PARK7/DJ1 Antibody

Specificity: This antibody is specific for the ~21k park7 protein.

Purification: Affinity Chromatography

Immunogen: Full length recombinant human park7 expressed in and purified from E. coli.

Isotype: IgG1

Application Details

Application Notes: Western blotting: 1/2000. Immunofluorescence: 1/500.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS Preservatives: 10 mM Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store the antibody undiluted (in aliquots) at -20°C. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for PARK7/DJ1

Target: PARK7/DJ1 (PARK7) (Parkinson Protein 7 (PARK7))

Alternative Name: dj-1,park7

Background: Park7, also known as DJ-1, is a member of the peptidase C56 family of proteins and is thought to function as a molecular chaperone. Mutations in park7 have been associated with autosomal recessive, early onset Parkinson's disease (Bonifati et al., 2003). Recently, park7 has been shown to inhibit microtubule associated protein 1B aggregation thus leading to neuronal apoptosis (Wang et al., 2011).

UniProt: O88767

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Proton Transport