PARK7/DJ1 antibody (AA 1-189)

Catalog No. ABIN5542009

The Mouse Monoclonal anti-PARK7/DJ1 antibody (Clone AT1E12) (ABIN5542009) specifically detects PARK7/DJ1 in WB, ICC, IF, FACS and EIA. The antibody is reactive with Human samples.

Quick Overview for PARK7/DJ1 antibody (AA 1-189) (ABIN5542009)

Target: PARK7/DJ1 (PARK7) (Parkinson Protein 7 (PARK7))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PARK7/DJ1 antibody is un-conjugated

Application: Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), Flow Cytometry (FACS), Enzyme Immunoassay (EIA)

Clone: AT1E12

Product Details anti-PARK7/DJ1 Antibody

Binding Specificity: AA 1-189

Purification: Protein-A affinity chromatography

Immunogen: Recombinant human Park7/DJ-1 (1-189aa) purified from E. coli

Isotype: IgG2b

Application Details

Application Notes: ELISA. Flow Cytometry. Immunocytochemistry/Immunofluorescence. Western blot / Immunoblot. The antibody has been tested by ELISA, Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended starting dilution is 1:1000.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS, pH 7.4 containing 0.02 % Sodium Azide and 10 % Glycerol

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for PARK7/DJ1

Target: PARK7/DJ1 (PARK7) (Parkinson Protein 7 (PARK7))

Alternative Name: dj-1,park7

Background: Parkinson disease (autosomal recessive, early onset) 7, also known as PARK7/DJ-1, has been shown to interact with EFCAB6 and protein inhibitor of activated STAT2. Defects in PARK7 are the cause of autosomal recessive early-onset Parkinson's disease 7. This protein belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death.

UniProt: Q99497

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Proton Transport