PDCL3 antibody (AA 1-239)

Catalog No. ABIN5542147

Product Details anti-PDCL3 Antibody

Target: PDCL3 (Phosducin-Like 3 (PDCL3))

Binding Specificity: AA 1-239

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PDCL3 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Purification: Protein-A affinity chromatography

Immunogen: Recombinant human PDCL3 (1-239aa) purified from E. coli.

Clone: AT8F9

Isotype: IgG1

Application Details

Application Notes: The antibody has been tested by ELISA, Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended starting dilution is 1:1000.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS, pH 7.4 containing 0.02 % Sodium Azide and 10 % Glycerol

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for PDCL3

Target: PDCL3 (Phosducin-Like 3 (PDCL3))

Alternative Name: pdcl3 (PDCL3 Products)

Synonyms: MGC78962 antibody, MGC130699 antibody, PDCL3 antibody, DKFZp469I1539 antibody, HTPHLP antibody, PHLP2A antibody, PHLP3 antibody, VIAF antibody, VIAF1 antibody, 1110061A19Rik antibody, C80025 antibody, Viaf1 antibody, viaf1 antibody, zgc:73170 antibody, phosducin like 3 antibody, phosducin like 3 L homeolog antibody, phosducin-like 3 antibody, PDCL3 antibody, pdcl3.L antibody, pdcl3 antibody, Pdcl3 antibody

Background: PDCL3 (phosducin-like 3), also known as VIAF1 (viral IAP-associated factor 1), VIAF, PHLP3 or HTPHLP, is a widely expressed protein that belongs to the phosducin-like family of proteins. phosducin-like family members associate with the cytosolic chaperonin complex (CCT) and regulate the folding of proteins. Localizing to the cytoplasm, PDCL3 does not appear to play a role in G protein signaling, but participates in the chaperone-assisted folding of proteins, such as beta Tubulin and Actin, that are involved in the regulation of cell cycle progression. More specifically, PDCL3, when associated with CCT, represses the ATPase activity of CCT and ultimately disrupts the folding of the Actin or tubulin substrates.

UniProt: Q9H2J4