DNMT3L antibody (AA 147-386)

Catalog No. ABIN5542515

The Mouse Monoclonal anti-DNMT3L antibody has been validated for ELISA and FACS. It is suitable to detect DNMT3L in samples from Human.

Quick Overview for DNMT3L antibody (AA 147-386) (ABIN5542515)

Target: DNMT3L (TRDMT1) (DNA (Cytosine-5-)-Methyltransferase 3 Like (TRDMT1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This DNMT3L antibody is un-conjugated

Application: ELISA, Flow Cytometry (FACS)

Clone: 2D10H11

Product Details anti-DNMT3L Antibody

Binding Specificity: AA 147-386

Purpose: DNMT3L Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human DNMT3L (AA: 147-386) expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Target Details for DNMT3L

Target: DNMT3L (TRDMT1) (DNA (Cytosine-5-)-Methyltransferase 3 Like (TRDMT1))

Alternative Name: DNMT3L

Background: CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a nuclear protein with similarity to DNA methyltransferases, but is not thought to function as a DNA methyltransferase as it does not contain the amino acid residues necessary for methyltransferase activity. However, it does stimulate de novo methylation by DNA cytosine methyltransferase 3 alpha and is thought to be required for the establishment of maternal genomic imprints. This protein also mediates transcriptional repression through interaction with histone deacetylase 1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Molecular Weight: 43.6 kDa

Gene ID: 29947

UniProt: Q9UJW3