Estrogen Receptor alpha antibody (Estrogen Receptor 1) (AA 2-185)

Details for Product anti-ESR1 Antibody No. ABIN5542593
Target
Binding Specificity
AA 2-185
42
31
29
27
26
24
23
21
21
18
17
16
16
16
15
15
15
13
11
11
10
8
7
6
5
5
5
5
4
4
4
4
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Rat
593
255
205
40
33
12
10
9
7
7
5
5
4
3
3
1
1
Host
Mouse
453
176
2
1
1
Clonality (Clone)
Monoclonal ()
Conjugate
This Estrogen Receptor alpha antibody is un-conjugated
42
24
24
17
16
13
12
12
12
12
12
11
6
6
6
6
6
4
4
4
4
4
4
4
4
4
4
4
4
4
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC), Immunohistochemistry (IHC), Western Blotting (WB)
445
211
206
143
103
80
78
55
54
18
16
16
13
13
11
9
7
3
2
1
1
1
1
1
1
1
1
1
1
1
Options
Immunogen Purified recombinant fragment of human ESR1 (AA 2-185) expressed in E. Coli.
Clone 6A6E8
Isotype IgG1
Target
Alternative Name ESR1 (ESR1 Antibody Abstract)
Background This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined.,
Molecular Weight 45.5kDa
HGNC 2101
Pathways Nuclear Receptor Transcription Pathway, EGFR Signaling Pathway, Retinoic Acid Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Ribonucleoprotein Complex Subunit Organization, Ribosome Assembly
Application Notes ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000, ICC: 1:200 - 1:1000, FCM: 1:200 - 1:400
Restrictions For Research Use only
Format Liquid
Buffer PBS with 0.05 % sodium azide
Storage 4 °C,-20 °C
Storage Comment 4°C, -20°C for long term storage
Images
Image no. 1 for anti-Estrogen Receptor 1 (ESR1) (AA 2-185) antibody (ABIN5542593) Western blot analysis using ESR1 mouse mAb against MOLT4 (1), Raji (2), MCF-7 (3), T4...
Image no. 2 for anti-Estrogen Receptor 1 (ESR1) (AA 2-185) antibody (ABIN5542593) Flow cytometric analysis of Hela cells using ESR1 mouse mAb (green) and negative cont...
Image no. 3 for anti-Estrogen Receptor 1 (ESR1) (AA 2-185) antibody (ABIN5542593) Immunofluorescence analysis of Hela cells using ESR1 mouse mAb. Blue: DRAQ5 fluoresce...
Image no. 4 for anti-Estrogen Receptor 1 (ESR1) (AA 2-185) antibody (ABIN5542593) Immunofluorescence analysis of Hela cells using ESR1 mouse mAb (green). Blue: DRAQ5 f...
Image no. 5 for anti-Estrogen Receptor 1 (ESR1) (AA 2-185) antibody (ABIN5542593) Immunohistochemical analysis of paraffin-embedded breast cancer tissues using ESR1 mo...
Image no. 6 for anti-Estrogen Receptor 1 (ESR1) (AA 2-185) antibody (ABIN5542593) Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen ...
Image no. 7 for anti-Estrogen Receptor 1 (ESR1) (AA 2-185) antibody (ABIN5542593) Immunohistochemical analysis of paraffin-embedded esophageal cancer tissues using ESR...
Image no. 8 for anti-Estrogen Receptor 1 (ESR1) (AA 2-185) antibody (ABIN5542593) Western blot analysis using ESR1 mAb against human ESR1 (AA: 2-185) recombinant prote...
Image no. 9 for anti-Estrogen Receptor 1 (ESR1) (AA 2-185) antibody (ABIN5542593) Western blot analysis using ESR1 mAb against HEK293 (1) and ESR1 (AA: 2-185)-hIgGFc t...