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Estrogen Receptor alpha antibody (AA 331-360)

ESR1 Reactivity: Human, Rat WB, ELISA, FACS, IF (cc) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN725300
  • Target See all Estrogen Receptor alpha (ESR1) Antibodies
    Estrogen Receptor alpha (ESR1) (Estrogen Receptor 1 (ESR1))
    Binding Specificity
    • 32
    • 30
    • 26
    • 23
    • 21
    • 21
    • 21
    • 17
    • 16
    • 16
    • 16
    • 16
    • 15
    • 15
    • 14
    • 12
    • 12
    • 10
    • 10
    • 10
    • 9
    • 7
    • 7
    • 7
    • 6
    • 6
    • 6
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    AA 331-360
    Reactivity
    • 487
    • 172
    • 169
    • 19
    • 18
    • 10
    • 7
    • 6
    • 5
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    Human, Rat
    Host
    • 398
    • 98
    • 2
    • 1
    Rabbit
    Clonality
    • 377
    • 124
    Polyclonal
    Conjugate
    • 223
    • 35
    • 24
    • 22
    • 19
    • 15
    • 15
    • 15
    • 15
    • 15
    • 15
    • 11
    • 8
    • 8
    • 8
    • 8
    • 8
    • 8
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    This Estrogen Receptor alpha antibody is un-conjugated
    Application
    • 294
    • 162
    • 141
    • 121
    • 99
    • 93
    • 80
    • 67
    • 40
    • 39
    • 24
    • 15
    • 10
    • 7
    • 7
    • 6
    • 5
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc))
    Predicted Reactivity
    Mouse,Dog,Cow,Rabbit
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from rat Estrogen Receptor alpha
    Isotype
    IgG
  • Application Notes
    WB 1:300-5000
    ELISA 1:500-1000
    FCM 1:20-100
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Expiry Date
    12 months
  • Zhou, Li, Wang, Cheng, Ding: "Estrogen receptor alpha is essential for the proliferation of prostatic smooth muscle cells stimulated by 17?-estradiol and insulin-like growth factor 1." in: Cell biochemistry and function, Vol. 29, Issue 2, pp. 120-5, (2011) (PubMed).

  • Target
    Estrogen Receptor alpha (ESR1) (Estrogen Receptor 1 (ESR1))
    Alternative Name
    Estrogen Receptor alpha (ESR1 Products)
    Synonyms
    LOC398734 antibody, AA420328 antibody, AU041214 antibody, ER-alpha antibody, ER[a] antibody, ERa antibody, ERalpha antibody, ESR antibody, Estr antibody, Estra antibody, Nr3a1 antibody, NR3A1 antibody, eralpha antibody, zfER[a] antibody, ER antibody, ESRA antibody, ESTRR antibody, Era antibody, akap12 antibody, cb27 antibody, esr1 antibody, fb72g12 antibody, id:ibd1202 antibody, sb:cb27 antibody, si:ch73-192g21.1 antibody, wu:fb72g12 antibody, wu:fc21c03 antibody, Esr antibody, RNESTROR antibody, ERALPHA antibody, er antibody, esr antibody, nr3a1 antibody, XER antibody, era antibody, esra antibody, ERbeta antibody, xesr-1 antibody, xlERalpha1 antibody, xlERalpha2 antibody, ESR1 antibody, estrogen receptor 1 L homeolog antibody, estrogen receptor 1 (alpha) antibody, estrogen receptor 1 antibody, A kinase (PRKA) anchor protein 12b antibody, esr1.L antibody, Esr1 antibody, ESR1 antibody, esr1 antibody, akap12b antibody
    Background

    Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p5 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements, the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3 (By similarity).

    Subcellular location: Nucleus

    Synonyms: Esr, ER-alpha, RNESTROR, Estrogen receptor, ER, Estradiol receptor, Nuclear receptor subfamily 3 group A member 1, Esr1, Estr, Nr3a1

    Gene ID
    24890
    UniProt
    P06211
    Pathways
    Nuclear Receptor Transcription Pathway, EGFR Signaling Pathway, Retinoic Acid Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Ribonucleoprotein Complex Subunit Organization, Ribosome Assembly
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