DOC2A antibody (AA 652-749)

Catalog No. ABIN5542714

Product Details anti-DOC2A Antibody

Target: DOC2A (Double C2-Like Domains, alpha (DOC2A))

Binding Specificity: AA 652-749

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This DOC2A antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunocytochemistry (ICC)

Purification: purified

Immunogen: Purified recombinant fragment of human DOC2 (AA: 652-749) expressed in E. coli.

Clone: 2H7C4

Isotype: IgG1

Application Details

Application Notes: ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: , ICC: 1:200 - 1:1000, FCM: 1:200 - 1:400

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: 4°C, -20°C for long term storage

Target Details for DOC2A

Target: DOC2A (Double C2-Like Domains, alpha (DOC2A))

Alternative Name: DOC2 (DOC2A Products)

Synonyms: DOC2A antibody, doc2-A antibody, Doc2 antibody, double C2 domain alpha antibody, double C2-like domains, alpha antibody, double C2, alpha antibody, DOC2A antibody, doc2a antibody, Doc2a antibody

Background:

Description: This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.,

Aliases: DAB2, DOC-2

Molecular Weight: 82.4 kDa

Gene ID: 1601

HGNC: 5899

Pathways: Synaptic Vesicle Exocytosis