HDAC4 antibody (C-Term)

Catalog No. ABIN5557481

The Rabbit Monoclonal anti-HDAC4 antibody (Clone 6B10) (ABIN5557481) specifically detects HDAC4 in WB, IF and ICC. The antibody is reactive with Human samples.

Quick Overview for HDAC4 antibody (C-Term) (ABIN5557481)

Target: HDAC4 (Histone Deacetylase 4 (HDAC4))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This HDAC4 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)

Clone: 6B10

Product Details anti-HDAC4 Antibody

Binding Specificity: C-Term

Purpose: HDAC4 Monoclonal Antibody

Cross-Reactivity: Human

Purification: Purified by Protein A.

Immunogen: Recombinant human HDAC4 protein, around C-terminal 100aa.

Isotype: IgG

Application Details

Application Notes: WB(1:300-5000), ICC/IF(1:50-100)

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for HDAC4

Target: HDAC4 (Histone Deacetylase 4 (HDAC4))

Alternative Name: HDAC4

Background:

Synonyms: HDAC4Ser246, HDAC4S246, p-HDAC4Ser246, p-HDAC4S246, HD 4, HD4, HDAC 4, HDAC A, HDACA, Histone Deacetylase 4, Histone Deacetylase A, KIAA0288, EC 3.5.1.98, HA6116, HDA4_CAEEL, Histone deacetylase 4, CeHDA-7, Histone deacetylase 7.

Background: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. [provided by RefSeq, Jul 2008].

Gene ID: 9759

UniProt: P56524

Pathways: Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process