Recombinant Netrin 1 antibody

Catalog No. ABIN5564235

The Human Monoclonal anti-Netrin 1 antibody is suitable to detect Netrin 1 in samples from Human and Mouse. It has been validated for ELISA and Func.

Quick Overview for Recombinant Netrin 1 antibody (ABIN5564235)

Target: Netrin 1 (NTN1)

Antibody Type: Recombinant Antibody

Reactivity: Human, Mouse

Host: Human

Clonality: Monoclonal

Conjugate: This Netrin 1 antibody is un-conjugated

Application: ELISA, Functional Studies (Func)

Clone: 2F5

Product Details anti-Netrin 1 Antibody

Purpose: anti-Netrin-1 (human), mAb (rec.) (blocking) (2F5) (preservative-free)

Specificity: Recognizes human and mouse Netrin-1. Does not recognize Netrin-4. Blocks human and mouse Netrin-1 activity on tumor cell lines in vitro and in vivo. Inhibits Netrin-1-enhanced infectivity of Hepatitis C Virus particles.

No Cross-Reactivity: Mouse (Murine)

Cross-Reactivity (Details): Does not recognize Netrin-4. Blocks human and mouse Netrin-1 activity on tumor cell lines in vitro and in vivo. Inhibits Netrin-1-enhanced infectivity of Hepatitis C Virus particles.

Characteristics: Recombinant Antibody. Recognizes human and mouse Netrin-1. Does not recognize Netrin-4. Blocks human and mouse Netrin-1 activity on tumor cell lines in vitro and in vivo. Inhibits Netrin-1-enhanced infectivity of Hepatitis C Virus particles. Species cross-reactivity: Human, Mouse. Clone: 2F5. Isotype: Human IgG2lambda. Applications: ELISA, FUNC (Blocking). Host: HEK 293 cells. Liquid. In PBS containing 10 % glycerol. Netrin-1 controls guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serves as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Netrin-1 is also involved in tumorigenesis by regulating apoptosis. Netrin-1 promotes atherosclerosis by retaining macrophages in the artery wall. Netrin-1 also governs induced pluripotent stem cell (iPS) formation and improves reprogramming efficiency of human and mouse somatic cells by limiting apoptosis mediated by Netrin-1 receptors DCC or UNC5b.

Purity: >95 % (SDS-PAGE)

Immunogen: Recombinant human Netrin-1.

Isotype: IgG2 lambda

Application Details

Comment:

anti-Netrin-1 (human), mAb (rec.) (blocking) (2F5) is composed of human variable regions (VH and VL) (lambda-chain) of immunoglobulin fused to the human lgG2 Fc domain.For negative control see Prod. No. AG-27B-0020PF.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: In PBS.

Handling Advice: After opening, prepare aliquots and store at -20 °C.Avoid freeze/thaw cycles.

Storage: 4 °C,-20 °C

Storage Comment:

+4°C

-20°C

Stable for at least 1 year after receipt when stored at -20°C.

Expiry Date: 12 months

Target Details for Netrin 1

Target: Netrin 1 (NTN1)

Alternative Name: Netrin-1

Background:

Alternate Names/Synonyms: NTN1, NP01-014

Product Description: Netrin-1 controls guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serves as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Netrin-1 is also involved in tumorigenesis by regulating apoptosis. Netrin-1 promotes atherosclerosis by retaining macrophages in the artery wall. Netrin-1 also governs induced pluripotent stem cell (iPS) formation and improves reprogramming efficiency of human and mouse somatic cells by limiting apoptosis mediated by Netrin-1 receptors DCC or UNC5b.

UniProt: O95631

Pathways: Regulation of Cell Size