IL1F10 antibody

Catalog No. ABIN5564279

This Mouse Monoclonal antibody specifically detects IL1F10 in ELISA and WB. It exhibits reactivity toward Human and Mouse.

Quick Overview for IL1F10 antibody (ABIN5564279)

Target: IL1F10 (Interleukin 1 Family, Member 10 (Theta) (IL1F10))

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This IL1F10 antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Clone: Nhat-1

Product Details anti-IL1F10 Antibody

Purpose: anti-IL-38, mAb (Nhat-1)

Specificity: Recognizes human and mouse IL-38.

Characteristics: Monoclonal Antibody. Recognizes human and mouse IL-38. Isotype: Mouse IgG2bkappa. Clone: Nhat-1. Applications: ELISA, WB. Liquid. In PBS containing 10 % glycerol and 0.02 % sodium azide. IL-38 (IL-1F10) belongs to the IL-1 family of proteins. IL-38 is expressed in heart, placenta, fetal liver, spleen, thymus and tonsil. The expression in a variety of immune tissues and similarity to IL-1Ra suggest a role of IL-38 as a IL-1 family receptor antagonist. Il-38 inhibits IL-36 signaling by binding to IL-1R6. IL-38 (aa 20-152) is released from apoptotic cells to limit inflammatory macrophage and downstream Th17 activation by blocking IL1RAPL1 (Interleukin-1 receptor accessory protein-like 1, TIGIRR-2) signaling. IL-38 is unregulated during some autoimmune diseases such as Systemic Lupus Erythematosus.

Purity: >95 % (SDS-PAGE)

Immunogen: Recombinant human IL-38.

Isotype: IgG2b kappa

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: In PBS containing 10 % glycerol and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: After opening, prepare aliquots and store at -20 °C.Avoid freeze/thaw cycles.

Storage: 4 °C,-20 °C

Storage Comment:

+4°C

-20°C

Stable for at least 1 year after receipt when stored at -20°C.

Expiry Date: 12 months

Target Details for IL1F10

Target: IL1F10 (Interleukin 1 Family, Member 10 (Theta) (IL1F10))

Alternative Name: IL-38

Background:

Alternate Names/Synonyms: Interleukin-38, Interleukin-1 Family Member 10, IL-1F10

Product Description: IL-38 (IL-1F10) belongs to the IL-1 family of proteins. IL-38 is expressed in heart, placenta, fetal liver, spleen, thymus and tonsil. The expression in a variety of immune tissues and similarity to IL-1Ra suggest a role of IL-38 as a IL-1 family receptor antagonist. Il-38 inhibits IL-36 signaling by binding to IL-1R6. IL-38 (aa 20-152) is released from apoptotic cells to limit inflammatory macrophage and downstream Th17 activation by blocking IL1RAPL1 (Interleukin-1 receptor accessory protein-like 1, TIGIRR-2) signaling. IL-38 is unregulated during some autoimmune diseases such as Systemic Lupus Erythematosus.