C19ORF80 antibody

Catalog No. ABIN5564288

This Rabbit Polyclonal antibody specifically detects C19ORF80 in WB and ELISA. It exhibits reactivity toward Human.It has been mentioned in 1 publication

Quick Overview for C19ORF80 antibody (ABIN5564288)

Target: C19ORF80 (Chromosome 19 Open Reading Frame 80 (C19ORF80))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This C19ORF80 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-C19ORF80 Antibody

Purpose: anti-Betatrophin (human), pAb (IN108)

Specificity: Recognizes human betatrophin.

Characteristics: Polyclonal Antibody. Recognizes human ANGPTL8 [Betatrophin]. Source: Rabbit. Applications: ELISA, WB. Liquid. In PBS containing 10 % glycerol and 0.02 % sodium azide. ANGPTL8 (Angiopoietin-like protein 8, RIFL, Lipasin, Betatrophin) is a newly discovered secreted protein of 198 aa that was proposed to promote beta cell proliferation and improve glucose tolerance in mice. ANGPTL8 may also function in inhibition of lipase activity and on serum triglyceride regulation. ANGPTL8 is expressed in the liver and in white and brown adipose tissue of mice. In humans, ANGPTL8 is found to be predominantly expressed in the liver. ANGPTL8 levels are reduced by fasting and are elevated upon insulin resistance and during pregnancy. ANGPTL8, according to preliminary data could bind to the macrophage receptor Marco and also to RTN4R, a neuronal receptor. Recently, a study using ANGPTL8 KO mice showed that ANGPTL8 does not play a role in beta cell proliferation nor in glycemic control as previously thought, but regulates plasma triglyceride levels.

Immunogen: Recombinant human ANGPTL8 (betatrophin).

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: In PBS containing 10 % glycerol and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: After opening, prepare aliquots and store at -20 °C.Avoid freeze/thaw cycles.

Storage: 4 °C,-20 °C

Storage Comment:

+4°C

-20°C

Stable for at least 1 year after receipt when stored at -20°C.

Expiry Date: 12 months

References for anti-C19ORF80 antibody (ABIN5564288)

Sun, Liu, Li, Tang, Zou, Chen, Zheng, Jiang, Shi: "Transplantation of betatrophin-expressing adipose-derived mesenchymal stem cells induces β-cell proliferation in diabetic mice." in: International journal of molecular medicine, Vol. 39, Issue 4, pp. 936-948, (2017) (PubMed).

Target Details for C19ORF80

Target: C19ORF80 (Chromosome 19 Open Reading Frame 80 (C19ORF80))

Alternative Name: Betatrophin

Background:

Alternate Names/Synonyms: Angiopoietin-like Protein 8, ANGPTL8, Lipasin, Refeeding-induced Fat and Liver Protein, RIFL, Betatrophin

Product Description: ANGPTL8 (Angiopoietin-like protein 8, RIFL, Lipasin, Betatrophin) is a newly discovered secreted protein of 198 aa that was proposed to promote beta cell proliferation and improve glucose tolerance in mice. ANGPTL8 may also function in inhibition of lipase activity and on serum triglyceride regulation. ANGPTL8 is expressed in the liver and in white and brown adipose tissue of mice. In humans, ANGPTL8 is found to be predominantly expressed in the liver. ANGPTL8 levels are reduced by fasting and are elevated upon insulin resistance and during pregnancy. ANGPTL8, according to preliminary data could bind to the macrophage receptor Marco and also to RTN4R, a neuronal receptor. Recently, a study using ANGPTL8 KO mice showed that ANGPTL8 does not play a role in beta cell proliferation nor in glycemic control as previously thought, but regulates plasma triglyceride levels.