The Mouse Monoclonal anti-ATP2A1/SERCA1 antibody (Clone 4F11F6) (ABIN5611123) specifically detects ATP2A1/SERCA1 in WB and ELISA.
The antibody is reactive with Human, Mouse and Monkey samples.
This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in muscular excitation and contraction. Mutations in this gene cause some autosomal recessive forms of Brody disease, characterized by increasing impairment of muscular relaxation during exercise. Alternative splicing results in three transcript variants encoding different isoforms.