BTRC antibody (AA 24-151)

Catalog No. ABIN5611131

The Mouse Monoclonal anti-BTRC antibody has been validated for WB, ELISA, IHC and FACS. It is suitable to detect BTRC in samples from Human.

Quick Overview for BTRC antibody (AA 24-151) (ABIN5611131)

Target: BTRC (beta-Transducin Repeat Containing (BTRC))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This BTRC antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS)

Clone: 4C5D8

Product Details anti-BTRC Antibody

Binding Specificity: AA 24-151

Purpose: BTRC Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human BTRC (AA: 24-151) expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Target Details for BTRC

Target: BTRC (beta-Transducin Repeat Containing (BTRC))

Alternative Name: BTRC

Background: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class, in addition to an F-box, this protein contains multiple WD-40 repeats. The encoded protein mediates degradation of CD4 via its interaction with HIV-1 Vpu. It has also been shown to ubiquitinate phosphorylated NFKBIA (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha), targeting it for degradation and thus activating nuclear factor kappa-B. Alternatively spliced transcript variants have been described. A related pseudogene exists in chromosome 6.

Molecular Weight: 68.9 kDa

Gene ID: 8945

UniProt: Q9Y297

Pathways: Cell Division Cycle, Hedgehog Signaling