GRM8 antibody (AA 440-583)

Catalog No. ABIN5611162

This anti-GRM8 antibody is a Mouse Monoclonal antibody detecting GRM8 in WB, ELISA and FACS. Suitable for Human.

Quick Overview for GRM8 antibody (AA 440-583) (ABIN5611162)

Target: GRM8 (Glutamate Receptor, Metabotropic 8 (GRM8))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This GRM8 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Clone: 4C1C1

Product Details anti-GRM8 Antibody

Binding Specificity: AA 440-583

Purpose: GRM8 Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human GRM8 (AA: 440-583) expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Target Details for GRM8

Target: GRM8 (Glutamate Receptor, Metabotropic 8 (GRM8))

Alternative Name: GRM8

Background: L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Molecular Weight: 101.7 kDa

Gene ID: 2918

UniProt: O00222

Pathways: cAMP Metabolic Process, Synaptic Membrane