BCL2L10 antibody (AA 31-186)

Catalog No. ABIN5611303

Product Details anti-BCL2L10 Antibody

Target: BCL2L10 (BCL2-Like 10 (Apoptosis Facilitator) (BCL2L10))

Binding Specificity: AA 31-186

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This BCL2L10 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FACS), Neutralization (Neut)

Purification: purified

Immunogen: Purified recombinant fragment of human BCL2L10 (AA: 31-186) expressed in E. coli.

Clone: 8A11G12

Isotype: IgG2a

Application Details

Application Notes: ELISA: 1:10000, WB: 1:500 - 1:2000, ICC: N/A, FCM: 1:200 - 1:400, IHC: N/A

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: 4°C, -20°C for long term storage

Target Details for BCL2L10

Target: BCL2L10 (BCL2-Like 10 (Apoptosis Facilitator) (BCL2L10))

Alternative Name: BCL2L10 (BCL2L10 Products)

Synonyms: BCL-B antibody, Boo antibody, Diva antibody, AA420380 antibody, AU023065 antibody, C85687 antibody, NR-13 antibody, mcl1l antibody, nr13 antibody, sb:cb78 antibody, BCL2 like 10 antibody, Bcl2-like 10 antibody, BCL2-like 10 (apoptosis facilitator) antibody, BCL2L10 antibody, Bcl2l10 antibody, bcl2l10 antibody

Background:

Description: The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains conserved BH4, BH1 and BH2 domains. This protein can interact with other members of BCL-2 protein family including BCL2, BCL2L1/BCL-X(L), and BAX. Overexpression of this gene has been shown to suppress cell apoptosis possibly through the prevention of cytochrome C release from the mitochondria, and thus activating caspase-3 activation. The mouse counterpart of this protein is found to interact with Apaf1 and forms a protein complex with Caspase 9, which suggests the involvement of this protein in APAF1 and CASPASE 9 related apoptotic pathway.

Aliases: Boo, Diva, BCL-B, bcl2-L-10

Molecular Weight: 22 kDa

Gene ID: 10017

HGNC: 10017

Pathways: Positive Regulation of Endopeptidase Activity