CASR antibody (N-Term)

Catalog No. ABIN5611429

The Rabbit Polyclonal anti-CASR antibody (ABIN5611429) specifically detects CASR in WB and IHC (p). The antibody is reactive with Human and Rat samples.

Quick Overview for CASR antibody (N-Term) (ABIN5611429)

Target: CASR (Calcium-Sensing Receptor (CASR))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CASR antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-CASR Antibody

Binding Specificity: N-Term

Specificity: This antibody reacts to Calcium-Sensing Receptor CASR (CASR).

Purification: Immunoaffinity Chromatography

Immunogen: CASR antibody was raised against a synthetic peptide from N-terminal of rat calcium sensing receptor Genename: CASR

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: 10 mM PBS, pH 7.4 containing BSA, sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for CASR

Target: CASR (Calcium-Sensing Receptor (CASR))

Alternative Name: CaSR

Background: CASR, a Calcium-Sensing Receptor, functions as a sensor in parathyroid and kidney to determine extracellular calcium concentration and to maintain calcium homeostasis. This receptor regulates both secretion of parathyroid hormone and excretion of urinary calcium. Mutations that inactivate CASR cause familial hypocalciuric hypercalcemia, which is also correlated with hyperparathyroidism. On the other hand, mutations that activate CASR cause autosomal dominant hypocalcemia. Hjalm et al. (2001) and Awata et al. (2001) have identified the binding of filamin-1 to the C-terminal tail of CASR, which may contribute to its localization in caveolae, link it to the actin-based cytoskeleton, and participate in CASR-mediated activation of MAPK. Multiple isoforms for CASR are produced by alternative splicing.Synonyms: Extracellular calcium-sensing receptor, GPRC2A, PCAR1, Parathyroid Cell calcium-sensing receptor

Gene ID: 846

NCBI Accession: NP_000379

UniProt: P41180

Pathways: Positive Regulation of Peptide Hormone Secretion, Carbohydrate Homeostasis