ADAM17 antibody (AA 215-314)

Catalog No. ABIN563080

This Mouse Monoclonal antibody specifically detects ADAM17 in WB, ELISA, IHC (p) and PLA. It exhibits reactivity toward Humanand has been mentioned in 1 publication.

Quick Overview for ADAM17 antibody (AA 215-314) (ABIN563080)

Target: ADAM17 (ADAM Metallopeptidase Domain 17 (ADAM17))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This ADAM17 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Proximity Ligation Assay (PLA)

Clone: 1F6

Product Details anti-ADAM17 Antibody

Binding Specificity: AA 215-314

Purpose: Mouse monoclonal antibody raised against a partial recombinant ADAM17.

Sequence: RADPDPMKNT CKLLVVADHR FYRYMGRGEE STTTNYLIEL IDRVDDIYRN TSWDNAGFKG YGIQIEQIRI LKSPQEVKPG EKHYNMAKSY PNEEKDAWDV

Cross-Reactivity: Human

Characteristics: Antibody Reactive Against Recombinant Protein.

Immunogen: ADAM17 (NP_003174, 215 a.a. ~ 314 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Isotype: IgG2b

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: In 1x PBS, pH 7.4

Handling Advice: Aliquot to avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

References for anti-ADAM17 antibody (ABIN563080)

Kahlert, Weber, Mogler, Bergmann, Schirmacher, Kenngott, Matterne, Mollberg, Rahbari, Hinz, Koch, Aigner, Weitz: "Increased expression of ALCAM/CD166 in pancreatic cancer is an independent prognostic marker for poor survival and early tumour relapse." in: British journal of cancer, Vol. 101, Issue 3, pp. 457-64, (2009) (PubMed).

Target Details for ADAM17

Target: ADAM17 (ADAM Metallopeptidase Domain 17 (ADAM17))

Alternative Name: ADAM17

Background: Full Gene Name: ADAM metallopeptidase domain 17
Synonyms: CD156b,MGC71942,TACE,cSVP

Gene ID: 6868

NCBI Accession: NM_003183

Pathways: Notch Signaling, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Response to Growth Hormone Stimulus