CD41, CD61 antibody (PAC-1 epitope)

Catalog No. ABIN5633262

This Mouse Monoclonal antibody specifically detects CD41, CD61 in FACS, IP and ICC. It exhibits reactivity toward Human.

Quick Overview for CD41, CD61 antibody (PAC-1 epitope) (ABIN5633262)

Target: CD41, CD61 (CD41,CD61)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD41, CD61 antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunoprecipitation (IP), Immunocytochemistry (ICC)

Clone: PAC-1

Product Details anti-CD41, CD61 Antibody

Binding Specificity: PAC-1 epitope

Purpose: Anti-Hu CD41/CD61 (PAC-1 epitope) Purified

Specificity: The mouse monoclonal antibody PAC-1 recognizes an extracellular activation-induced conformational epitope PAC-1 on CD41/CD61 complex (gpIIb/IIIa), also known as integrin alpha IIb beta 3, a receptor which mediates platelet aggregation.

Cross-Reactivity (Details): Human

Purification: Purified by sequential steps of physicochemical fractionation (differential precipitation and solid-phase chromatography methods).

Purity: > 95 % (by SDS-PAGE)

Immunogen: Human platelets

Isotype: IgM kappa

Application Details

Application Notes: Flow cytometry: Recommended dilution: 2-4 μg/mL.

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Tris buffered saline (TBS), pH 8.0, 15 mM sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store at 2-8°C. Do not freeze.

Target Details for CD41, CD61

Target: CD41, CD61 (CD41,CD61)

Alternative Name: CD41/CD61

Background: CD41 (platelet glycoprotein IIb, integrin alpha IIb) is composed of two subunits (120 kDa transmembrane alpha chain and 23 kDa extracellular beta chain) and interacts with CD61 (platelet glycoprotein IIIa, integrin beta 3) in the presence of calcium to form a functional adhesive protein receptor. CD41/CD61 complex is one of the earliest markers of the megakaryocytic lineage. Upon blood vessel damage, this receptor binds to a variety of proteins including von Willebrand factor, fibrinogen, fibronectin and vitronectin, and it is involved in platelet aggregation.,platelet GPIIb, Integrin alpha-Iib, GPalpha IIb, GPIIb, GT, GP3A, platelet GPIIIa