RAPGEF2 antibody (AA 1398-1487)

Catalog No. ABIN564181

This Mouse Monoclonal antibody specifically detects RAPGEF2 in WB and ELISA. It exhibits reactivity toward Human and has been mentioned in 3+ publications.

Quick Overview for RAPGEF2 antibody (AA 1398-1487) (ABIN564181)

Target: RAPGEF2 (Rap Guanine Nucleotide Exchange Factor (GEF) 2 (RAPGEF2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This RAPGEF2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Clone: 1E8

Product Details anti-RAPGEF2 Antibody

Binding Specificity: AA 1398-1487

Purpose: Mouse monoclonal antibody raised against a partial recombinant RAPGEF2.

Sequence: PITDFPEGHS HPARKPPDYN VALQRSRMVA RSSDTAGPSS VQQPHGHPTS SRPVNKPQWH KPNESDPRLA PYQSQGFSTE EDEDEQVSAV

Cross-Reactivity: Human

Characteristics: Antibody Reactive Against Recombinant Protein.

Immunogen: RAPGEF2 (XP_376350, 1398 a.a. ~ 1487 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: In 1x PBS, pH 7.4

Handling Advice: Aliquot to avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

References for anti-RAPGEF2 antibody (ABIN564181)

Gloerich, ten Klooster, Vliem, Koorman, Zwartkruis, Clevers, Bos: "Rap2A links intestinal cell polarity to brush border formation." in: Nature cell biology, Vol. 14, Issue 8, pp. 793-801, (2012) (PubMed).

Pannekoek, van Dijk, Chan, Huveneers, Linnemann, Spanjaard, Brouwer, van der Meer, Zwartkruis, Rehmann, de Rooij, Bos: "Epac1 and PDZ-GEF cooperate in Rap1 mediated endothelial junction control." in: Cellular signalling, Vol. 23, Issue 12, pp. 2056-64, (2011) (PubMed).

Letschka, Kollmann, Pfeifhofer-Obermair, Lutz-Nicoladoni, Obermair, Fresser, Leitges, Hermann-Kleiter, Kaminski, Baier: "PKC-theta selectively controls the adhesion-stimulating molecule Rap1." in: Blood, Vol. 112, Issue 12, pp. 4617-27, (2008) (PubMed).

Target Details for RAPGEF2

Target: RAPGEF2 (Rap Guanine Nucleotide Exchange Factor (GEF) 2 (RAPGEF2))

Alternative Name: RAPGEF2

Background: Full Gene Name: Rap guanine nucleotide exchange factor (GEF) 2
Synonyms: CNrasGEF,NRAPGEP,PDZ-GEF1,PDZGEF1,RA-GEF,Rap-GEP

Gene ID: 9693

NCBI Accession: XM_376350

Pathways: Neurotrophin Signaling Pathway