RAPGEF2 antibody (AA 190-270)

Catalog No. ABIN7231162

The Rabbit Polyclonal anti-RAPGEF2 antibody (ABIN7231162) specifically detects RAPGEF2 in WB and ELISA. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for RAPGEF2 antibody (AA 190-270) (ABIN7231162)

Target: RAPGEF2 (Rap Guanine Nucleotide Exchange Factor (GEF) 2 (RAPGEF2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RAPGEF2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-RAPGEF2 Antibody

Binding Specificity: AA 190-270

Purpose: Rabbit Anti-RPGF2 Polyclonal Antibody

Specificity: The antibody detects endogenous levels of RPGF2 protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human RPGF2 protein at AA range: 190-270

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for RAPGEF2

Target: RAPGEF2 (Rap Guanine Nucleotide Exchange Factor (GEF) 2 (RAPGEF2))

Alternative Name: RPGF2

Background: Rap guanine nucleotide exchange factor 2, Cyclic nucleotide ras GEF, CNrasGEF, Neural RAP guanine nucleotide exchange protein, nRap GEP, PDZ domain-containing guanine nucleotide exchange factor 1, PDZ-GEF1, RA-GEF-1, Ras/Rap1-associating GEF-1RAPGEF2 (Rap Guanine Nucleotide Exchange Factor 2) is a Protein Coding gene. Among its related pathways are RET signaling and G-protein signaling_Rap1A regulation pathway. Members of the RAS subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF2, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation.

Molecular Weight: 164kD

Gene ID: 9693

UniProt: Q9Y4G8

Pathways: Neurotrophin Signaling Pathway