MC1 Receptor antibody (AA 290-317)

Catalog No. ABIN5647059

This Rabbit Polyclonal antibody specifically detects MC1 Receptor in WB. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for MC1 Receptor antibody (AA 290-317) (ABIN5647059)

Target: MC1 Receptor (MC1R) (Melanocortin 1 Receptor (MC1R))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MC1 Receptor antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-MC1 Receptor Antibody

Binding Specificity: AA 290-317

Purification: Antigen affinity purified

Immunogen: Amino acids 290-317 (NAIIDPLIYAFHSQELRRTLKEVLTCSW) from the human protein were used as the immunogen for the MC1R antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the MC1R antibody should be determined by the researcher.\. WB: 0.5-1 μg/mL

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the MC1R antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for MC1 Receptor

Target: MC1 Receptor (MC1R) (Melanocortin 1 Receptor (MC1R))

Alternative Name: MC1 Receptor

Background: The Melanocortin 1 receptor (MC1R), mapped to 16q24.3, is also known as MSHR. This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation.

UniProt: Q01726

Pathways: cAMP Metabolic Process, Feeding Behaviour