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MC1 Receptor antibody (AA 205-232)

MC1R Reactivity: Human WB Host: Mouse Monoclonal 578CT6-2-3 unconjugated
Catalog No. ABIN1537697
  • Target See all MC1 Receptor (MC1R) Antibodies
    MC1 Receptor (MC1R) (Melanocortin 1 Receptor (MC1R))
    Binding Specificity
    • 16
    • 15
    • 11
    • 5
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 205-232
    Reactivity
    • 59
    • 23
    • 11
    • 4
    • 3
    • 1
    • 1
    Human
    Host
    • 62
    • 9
    Mouse
    Clonality
    • 69
    • 2
    Monoclonal
    Conjugate
    • 30
    • 8
    • 5
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    This MC1 Receptor antibody is un-conjugated
    Application
    • 52
    • 29
    • 26
    • 26
    • 14
    • 12
    • 8
    • 8
    • 7
    • 4
    • 2
    Western Blotting (WB)
    Purification
    This antibody is prepared by Euglobin precipitation followed by dialysis against PBS.
    Immunogen
    This MC1R antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 205-232 amino acids from the Central region of human MC1R.
    Clone
    578CT6-2-3
    Isotype
    IgM
    Top Product
    Discover our top product MC1R Primary Antibody
  • Application Notes
    WB: 1:100~250
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    MC1R Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, keep at -20 °C.
    Expiry Date
    6 months
  • Target
    MC1 Receptor (MC1R) (Melanocortin 1 Receptor (MC1R))
    Alternative Name
    MC1R (MC1R Products)
    Synonyms
    CMM5 antibody, MSH-R antibody, SHEP2 antibody, Mshra antibody, Tob antibody, e antibody, MC1-R antibody, MSHR antibody, mc1r antibody, MC1R antibody, TUBB3 antibody, melanocortin 1 receptor antibody, melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) antibody, MC1R antibody, Mc1r antibody, mc1r antibody, mc1r_par1 antibody
    Background
    This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation. [provided by RefSeq].
    Molecular Weight
    34706
    Gene ID
    4157
    NCBI Accession
    NP_002377
    UniProt
    Q01726
    Pathways
    cAMP Metabolic Process, Feeding Behaviour
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