Thrombopoietin antibody

Catalog No. ABIN5647289

The Rabbit Polyclonal anti-Thrombopoietin antibody (ABIN5647289) specifically detects Thrombopoietin in WB, ELISA and IHC (p). The antibody is reactive with Rat and Mouse samples.

Quick Overview for Thrombopoietin antibody (ABIN5647289)

Target: Thrombopoietin (THPO)

Reactivity: Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Thrombopoietin antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-Thrombopoietin Antibody

Purification: Antigen affinity purified

Immunogen: Amino acids S22-H259 from the mouse protein were used as the immunogen for the Thrombopoietin antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Thrombopoietin antibody should be determined by the researcher.\. WB: 0.5-1 μg/mL,IHC (FFPE): 1-2 μg/mL,ELISA: 0.1-0.5 μg/mL (mouse protein tested, request BSA-free format for coating)

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the Thrombopoietin antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for Thrombopoietin

Target: Thrombopoietin (THPO)

Alternative Name: Thrombopoietin / THPO

Background: Thrombopoietin (THPO), also known as megakaryocyte growth and development factor (MGDF), is a protein that in humans is encoded by the THPO gene. Megakaryocytopoiesis is the cellular development process that leads to platelet production. The main functional protein encoded by this gene is a humoral growth factor that is necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. This protein is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene. Mutations in this gene are the cause of thrombocythemia 1. Alternative promoter usage and differential splicing result in multiple transcript variants differing in the 5' UTR and/or coding region. Multiple AUG codons upstream of the main open reading frame (ORF) have been identified, and these upstream AUGs inhibit translation of the main ORF at different extent.

UniProt: P40226

Pathways: JAK-STAT Signaling, Hormone Activity