QPCT antibody (AA 262-359)

Catalog No. ABIN565166

The Mouse Polyclonal anti-QPCT antibody has been validated for WB and ELISA. It is suitable to detect QPCT in samples from Human. There are 4+ publications available.

Quick Overview for QPCT antibody (AA 262-359) (ABIN565166)

Target: QPCT (Glutaminyl-Peptide Cyclotransferase (QPCT))

Reactivity: Human

Host: Mouse

Clonality: Polyclonal

Conjugate: This QPCT antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-QPCT Antibody

Binding Specificity: AA 262-359

Purpose: Mouse polyclonal antibody raised against a partial recombinant QPCT.

Sequence: PNSARWFERL QAIEHELHEL GLLKDHSLEG RYFQNYSYGG VIQDDHIPFL RRGVPVLHLI PSPFPEVWHT MDDNEENLDE STIDNLNKIL QVFVLEYL

Cross-Reactivity: Human

Characteristics: Antibody Reactive Against Recombinant Protein.

Immunogen: QPCT (NP_036545, 262 a.a. ~ 359 a.a) partial recombinant protein with GST tag.

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 50 % glycerol

Handling Advice: Aliquot to avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

References for anti-QPCT antibody (ABIN565166)

Morawski, Schilling, Kreuzberger, Waniek, Jäger, Koch, Cynis, Kehlen, Arendt, Hartlage-Rübsamen, Demuth, Roßner: "Glutaminyl cyclase in human cortex: correlation with (pGlu)-amyloid-? load and cognitive decline in Alzheimer's disease." in: Journal of Alzheimer's disease : JAD, Vol. 39, Issue 2, pp. 385-400, (2014) (PubMed).

Chen, Huang, Kuo, Lo, Lee, Wang: "Inhibition of glutaminyl cyclase attenuates cell migration modulated by monocyte chemoattractant proteins." in: The Biochemical journal, Vol. 442, Issue 2, pp. 403-12, (2012) (PubMed).

Hartlage-Rübsamen, Morawski, Waniek, Jäger, Zeitschel, Koch, Cynis, Schilling, Schliebs, Demuth, Rossner: "Glutaminyl cyclase contributes to the formation of focal and diffuse pyroglutamate (pGlu)-A? deposits in hippocampus via distinct cellular mechanisms." in: Acta neuropathologica, Vol. 121, Issue 6, pp. 705-19, (2011) (PubMed).

Morawski, Hartlage-Rübsamen, Jäger, Waniek, Schilling, Schwab, McGeer, Arendt, Demuth, Rossner: "Distinct glutaminyl cyclase expression in Edinger-Westphal nucleus, locus coeruleus and nucleus basalis Meynert contributes to pGlu-Abeta pathology in Alzheimer's disease." in: Acta neuropathologica, Vol. 120, Issue 2, pp. 195-207, (2010) (PubMed).

Target Details for QPCT

Target: QPCT (Glutaminyl-Peptide Cyclotransferase (QPCT))

Alternative Name: QPCT

Background: Full Gene Name: glutaminyl-peptide cyclotransferase
Synonyms: GCT,QC

Gene ID: 25797

NCBI Accession: NM_012413