Recombinant TNF alpha (Infliximab Biosimilar) antibody

Catalog No. ABIN5668148

This Rabbit Chimeric antibody specifically detects TNF alpha (Infliximab Biosimilar) in FACS, in vivo and ELISA. It exhibits reactivity toward Human.

Quick Overview for Recombinant TNF alpha (Infliximab Biosimilar) antibody (ABIN5668148)

Target: TNF alpha (Infliximab Biosimilar)

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Chimeric

Conjugate: This TNF alpha (Infliximab Biosimilar) antibody is un-conjugated

Application: Flow Cytometry (FACS), In vivo Studies (in vivo), ELISA

Clone: CA2

Product Details anti-TNF alpha (Infliximab Biosimilar) Antibody

Purpose: Anti-TNF alpha [cA2 (Infliximab)], Rabbit IgG, kappa

Specificity: Binds to soluble and transmembrane forms of TNF-alpha and neutralizes its biological activity. Does not bind to TNF-beta.

Characteristics:

Original Species of Ab: Human

Original Format of Ab: IgG1

Purification: Protein A affinity purified

Purity: > 98 % as determined by SDS-PAGE

Endotoxin Level: Endotoxin is < 1.0 EU/mg as determined by the LAL method

Immunogen: Purified recombinant human TNF (rTNF).

Isotype: IgG kappa

Application Details

Application Notes: This antibody can be used to detect and neutralize human TNF alpha. Unlike Adalimumab (Ab00718), Infliximab does not bind to mouse TNF alpha (Arnoult 2017, PMID: 28584008).

Comment:

This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Target Details for TNF alpha (Infliximab Biosimilar)

Target: TNF alpha (Infliximab Biosimilar)

Target Type: Biosimilar

Background: TNF-α, TNFα, TNFSF, Tumor necrosis factor, Cachectin, TNF-alpha, Tumor necrosis factor ligand superfamily member 2, TNF-a, TNFa

UniProt: P01375