Recombinant TNF alpha (Infliximab Biosimilar) antibody
Quick Overview for Recombinant TNF alpha (Infliximab Biosimilar) antibody (ABIN7542939)
Target
Antibody Type
Reactivity
Host
Clonality
Conjugate
Application
Clone
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Purpose
- Anti-TNF alpha [cA2 (Infliximab)], Mouse IgG2a, kappa
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Specificity
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Binds to soluble and transmembrane forms of TNF-alpha and neutralizes its biological activity. Does not bind to TNF-beta.
Application Notes original Clone: This antibody can be used to detect and neutralize human TNF alpha. Unlike Adalimumab (Ab00718), Infliximab does not bind to mouse TNF alpha (Arnoult 2017, PMID: 28584008).
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Characteristics
- This chimeric mouse antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.
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Purification
- Protein A affinity purified
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Immunogen
- Purified recombinant human TNF (rTNF).
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Isotype
- IgG2a, kappa
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anti-TNF alpha (Infliximab Biosimilar) antibody
Reactivity: Human FACS, in vivo, ELISA Host: Human Chimeric cA2 unconjugated Recombinant Antibody
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Comment
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OriginalSpeciesName: Human
OriginalFormat: IgG1
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Restrictions
- For Research Use only
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Concentration
- 1 mg/mL
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Buffer
- PBS with 0.02 % Proclin 300.
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Preservative
- ProClin
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Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Storage
- 4 °C,-20 °C
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Storage Comment
- Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
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- TNF alpha (Infliximab Biosimilar)
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Target Type
- Biosimilar
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Background
- TNF-α, TNFα, TNFSF, Tumor necrosis factor, Cachectin, TNF-alpha, Tumor necrosis factor ligand superfamily member 2, TNF-a, TNFa
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UniProt
- P01375
Target
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