Recombinant C-Type Lectin Domain Family 4, Member M (CLEC4M) antibody

Catalog No. ABIN5668174

The Rabbit Chimeric anti-C-Type Lectin Domain Family 4, Member M antibody (Clone 16E7) (ABIN5668174) specifically detects C-Type Lectin Domain Family 4, Member M in IHC and FACS. The antibody is reactive with Human samples.

Quick Overview for Recombinant C-Type Lectin Domain Family 4, Member M (CLEC4M) antibody (ABIN5668174)

Target: C-Type Lectin Domain Family 4, Member M (CLEC4M)

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Chimeric

Conjugate: Un-conjugated

Application: Immunohistochemistry (IHC), Flow Cytometry (FACS)

Clone: 16E7

Product Details

Purpose: Anti-DC-SIGNR [16E7], Rabbit IgG, kappa

Specificity: Human CD299, which is an oligomeric type II transmembrane protein with a C-type lectin extracellular domain, the expression of which is restricted to immature DC, macrophages in the lung, and endothelial cells in the liver. It binds ICAM-3 and ICAM-7 to mediate the interaction of DC with T lymphocytes and endothelial cells in the initial stages of immune response and in the migratory behavior of DC. CD299 also binds the gp120 protein of HIV and the E2 envelope protein of HCV, thereby playing a role in viral infection.

Characteristics:

Original Species of Ab: Mouse

Original Format of Ab: IgG1

Purification: Protein A affinity purified

Immunogen: CD299

Isotype: IgG kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

This chimeric rabbit antibody was made using the variable domain sequences of the original murine IgG1 format, for improved compatibility with existing reagents, assays and techniques.

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Target Details

Target: C-Type Lectin Domain Family 4, Member M (CLEC4M)

Alternative Name: DC-SIGNR

Background: CD299, C-type lectin domain family 4 member M, CD209 antigen-like protein 1, DC-SIGN-related protein, CLEC4M, Dendritic cell-specific ICAM-3-grabbing non-integrin 2, DC-SIGN2, Liver/lymph node-specific ICAM-3-grabbing non-integrin, L-SIGN

UniProt: Q9H2X3