Recombinant ITGA4 (Natalizumab Biosimilar) antibody

Catalog No. ABIN5668196

This Human Monoclonal antibody specifically detects ITGA4 (Natalizumab Biosimilar) in FACS and BR. It exhibits reactivity toward Humanand has been mentioned in 1 publication.

Quick Overview for Recombinant ITGA4 (Natalizumab Biosimilar) antibody (ABIN5668196)

Target: ITGA4 (Natalizumab Biosimilar)

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Human

Clonality: Monoclonal

Conjugate: This ITGA4 (Natalizumab Biosimilar) antibody is un-conjugated

Application: Flow Cytometry (FACS), Blocking Reagent (BR)

Product Details anti-ITGA4 (Natalizumab Biosimilar) Antibody

Purpose: Anti-Integrin alpha 4 [Natalizumab], Human IgG4, kappa

Specificity: This antibody binds to the alpha 4 binds subunit of α4β1 (also known as very late antigen 4 [VLA-4] or CD49d-CD29) and α4β7 integrin

Characteristics:

Original Species of Ab: Human

Original Format of Ab: IgG4

Purification: Protein A affinity purified

Purity: > 98 % as determined by SDS-PAGE

Endotoxin Level: Endotoxin is < 1.0 EU/mg as determined by the LAL method

Immunogen: The RAMOS cell line, a non-EBV releasing cell line, injected into mice.

Isotype: IgG4 kappa

Application Details

Application Notes: This antibody binds to human integrin alpha 4 and has been used to treat Multiple Sclerosis and Crohn's Disease.

Comment:

NOT FOR THERAPEUTIC USE - This is a research-grade biosimilar.

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

References for anti-ITGA4 (Natalizumab Biosimilar) antibody (ABIN5668196)

Cegarra, Cameron, Chaves, Dabdoubi, Do, Genêt, Roudières, Shi, Tchepikoff, Lesuisse: "An innovative strategy to identify new targets for delivering antibodies to the brain has led to the exploration of the integrin family." in: PloS one, Vol. 17, Issue 9, pp. e0274667, (2022) (PubMed).

Target Details for ITGA4 (Natalizumab Biosimilar)

Target: ITGA4 (Natalizumab Biosimilar)

Background: CD49D, alpha 4 subunit of VLA-4 receptor, ITGA4, Integrin alpha-IV

UniProt: P13612