Recombinant ITGA4 (Natalizumab Biosimilar) antibody
Quick Overview for Recombinant ITGA4 (Natalizumab Biosimilar) antibody (ABIN7487736)
Target
Antibody Type
Reactivity
Host
Clonality
Conjugate
Application
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Purpose
- Anti-Integrin alpha 4 [Natalizumab], Mouse IgG1, kappa
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Specificity
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This antibody binds to the alpha 4 binds subunit of α4β1 (also known as very late antigen 4 [VLA-4] or CD49d-CD29) and α4β7 integrin
Application Notes original Clone: This antibody binds to human integrin alpha 4 and has been used to treat Multiple Sclerosis and Crohn's Disease.
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Characteristics
- This chimeric mouse antibody was made using the variable domain sequences of the original Human IgG4 format, for improved compatibility with existing reagents, assays and techniques.
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Purification
- Protein A affinity purified
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Immunogen
- The RAMOS cell line, a non-EBV releasing cell line, injected into mice.
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Isotype
- IgG1, kappa
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anti-ITGA4 (Natalizumab Biosimilar) antibody
Research Grade Reactivity: Human FACS Host: Humanized Monoclonal unconjugated Recombinant Antibody
anti-ITGA4 (Natalizumab Biosimilar) antibodyReactivity: Human FACS, BR Host: Rabbit Chimeric unconjugated Recombinant Antibody
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Comment
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OriginalSpeciesName: Human
OriginalFormat: IgG4
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Restrictions
- For Research Use only
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Concentration
- 1 mg/mL
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Buffer
- PBS with 0.02 % Proclin 300.
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Preservative
- ProClin
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Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Storage
- 4 °C,-20 °C
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Storage Comment
- Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
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- ITGA4 (Natalizumab Biosimilar)
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Background
- CD49D, alpha 4 subunit of VLA-4 receptor, ITGA4, Integrin alpha-IV
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UniProt
- P13612
Target
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