Recombinant ITGA4 (Natalizumab Biosimilar) antibody

Catalog No. ABIN5668197

The Rabbit Chimeric anti-ITGA4 (Natalizumab Biosimilar) antibody has been validated for FACS and BR. It is suitable to detect ITGA4 (Natalizumab Biosimilar) in samples from Human.

Quick Overview for Recombinant ITGA4 (Natalizumab Biosimilar) antibody (ABIN5668197)

Target: ITGA4 (Natalizumab Biosimilar)

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Chimeric

Conjugate: This ITGA4 (Natalizumab Biosimilar) antibody is un-conjugated

Application: Flow Cytometry (FACS), Blocking Reagent (BR)

Product Details anti-ITGA4 (Natalizumab Biosimilar) Antibody

Purpose: Anti-Integrin alpha 4 [Natalizumab], Rabbit IgG, kappa

Specificity: This antibody binds to the alpha 4 binds subunit of α4β1 (also known as very late antigen 4 [VLA-4] or CD49d-CD29) and α4β7 integrin

Characteristics:

Original Species of Ab: Human

Original Format of Ab: IgG4

Purification: Protein A affinity purified

Purity: > 98 % as determined by SDS-PAGE

Endotoxin Level: Endotoxin is < 1.0 EU/mg as determined by the LAL method

Immunogen: The RAMOS cell line, a non-EBV releasing cell line, injected into mice.

Isotype: IgG kappa

Application Details

Application Notes: This antibody binds to human integrin alpha 4 and has been used to treat Multiple Sclerosis and Crohn's Disease.

Comment:

NOT FOR THERAPEUTIC USE - This is a research-grade biosimilar. This chimeric rabbit antibody was made using the variable domain sequences of the original human IgG4 format, for improved compatibility with existing reagents, assays and techniques.

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Target Details for ITGA4 (Natalizumab Biosimilar)

Target: ITGA4 (Natalizumab Biosimilar)

Background: CD49D, alpha 4 subunit of VLA-4 receptor, ITGA4, Integrin alpha-IV

UniProt: P13612