RICTOR antibody (AA 1-98)

Catalog No. ABIN566975

There are 4+ publications for this product available. The Mouse Monoclonal anti-RICTOR antibody is suitable to detect RICTOR in samples from Human. It has been validated for WB, ELISA, IHC (p) and IP.

Quick Overview for RICTOR antibody (AA 1-98) (ABIN566975)

Target: RICTOR (RPTOR Independent Companion of mTOR, Complex 2 (RICTOR))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This RICTOR antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP)

Clone: 1F3

Product Details anti-RICTOR Antibody

Binding Specificity: AA 1-98

Purpose: Mouse monoclonal antibody raised against a partial recombinant RICTOR.

Sequence: MAAIGRGRSL KNLRVRGRND SGEENVPLDL TREPSDNLRE ILQNVARLQG VSNMRKLGHL NNFTKLLCDI GHSEEKLGFH YEDIIICLRL ALLNEAKE

Cross-Reactivity: Human

Characteristics: Antibody Reactive Against Recombinant Protein.

Immunogen: RICTOR (NP_689969, 1 a.a. ~ 98 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Isotype: IgG2b

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: In 1x PBS, pH 7.4

Handling Advice: Aliquot to avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

References for anti-RICTOR antibody (ABIN566975)

Wu, Schneider, Platen, Mitra, Blazek, Zengerle, Schüle, Meier: "In situ characterization of the mTORC1 during adipogenesis of human adult stem cells on chip." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 113, Issue 29, pp. E4143-50, (2016) (PubMed).

Pópulo, Tavares, Faustino, Nunes, Lopes, Soares: "GNAQ and BRAF mutations show differential activation of the mTOR pathway in human transformed cells." in: PeerJ, Vol. 1, pp. e104, (2013) (PubMed).

Faustino, Couto, Pópulo, Rocha, Pardal, Cameselle-Teijeiro, Lopes, Sobrinho-Simões, Soares: "mTOR pathway overactivation in BRAF mutated papillary thyroid carcinoma." in: The Journal of clinical endocrinology and metabolism, Vol. 97, Issue 7, pp. E1139-49, (2012) (PubMed).

Naïmi, Gautier, Chaussade, Valverde, Accili, Van Obberghen: "Nuclear forkhead box O1 controls and integrates key signaling pathways in hepatocytes." in: Endocrinology, Vol. 148, Issue 5, pp. 2424-34, (2007) (PubMed).

Target Details for RICTOR

Target: RICTOR (RPTOR Independent Companion of mTOR, Complex 2 (RICTOR))

Alternative Name: RICTOR

Background: Full Gene Name: rapamycin-insensitive companion of mTOR
Synonyms: DKFZp686B11164,KIAA1999,MGC39830,mAVO3

Gene ID: 253260

NCBI Accession: NM_152756

Pathways: Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Actin Filament Polymerization, CXCR4-mediated Signaling Events