XRN2 antibody (C-Term)

Catalog No. ABIN5671406

This anti-XRN2 antibody is a Rabbit Polyclonal antibody detecting XRN2 in WB. Suitable for Mouse.

Quick Overview for XRN2 antibody (C-Term) (ABIN5671406)

Target: XRN2 (5'-3' Exoribonuclease 2 (XRN2))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This XRN2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-XRN2 Antibody

Binding Specificity: C-Term

Sequence: QNAAFQPNQY QMLGGPGGYP PRRDDHRGGR QGYPREGRKY PLPPPSGRYS

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of Mouse XRN2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for XRN2

Target: XRN2 (5'-3' Exoribonuclease 2 (XRN2))

Alternative Name: XRN2

Background: Possesses 5'->3' exoribonuclease activity. May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. Binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G-rich pause sites.

Protein Size: 951

Gene ID: 24128

NCBI Accession: NM_011917, NP_036047

UniProt: Q9DBR1