SPG21 antibody (N-Term)

Catalog No. ABIN5671445

This Rabbit Polyclonal antibody specifically detects SPG21 in WB. It exhibits reactivity toward Human.

Quick Overview for SPG21 antibody (N-Term) (ABIN5671445)

Target: SPG21 (Spastic Paraplegia 21 (SPG21))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SPG21 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-SPG21 Antibody

Binding Specificity: N-Term

Sequence: GTVPLKKIIV DDDDSKIWSL YDAGPRSIRC PLIFLPPVSG TADVFFRQIL

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of Human SPG21

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for SPG21

Target: SPG21 (Spastic Paraplegia 21 (SPG21))

Alternative Name: SPG21

Background: The protein encoded by this gene binds to the hydrophobic C-terminal amino acids of CD4 which are involved in repression of T cell activation. The interaction with CD4 is mediated by the noncatalytic alpha/beta hydrolase fold domain of this protein. It is thus proposed that this gene product modulates the stimulatory activity of CD4. Mutations in this gene are associated with autosomal recessive spastic paraplegia 21 (SPG21), also known as mast syndrome. Alternative splicing results in multiple transcript variants.

Alias Symbols: MAST, ACP33, GL010, BM-019

Protein Size: 281

Gene ID: 51324

NCBI Accession: NM_001127889, NP_001121361