SMEK1 antibody (C-Term)

Catalog No. ABIN5672643

This Rabbit Polyclonal antibody specifically detects SMEK1 in WB. It exhibits reactivity toward Human.

Quick Overview for SMEK1 antibody (C-Term) (ABIN5672643)

Target: SMEK1 (Serine/threonine-Protein Phosphatase 4 Regulatory Subunit 3A (SMEK1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SMEK1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-SMEK1 Antibody

Binding Specificity: C-Term

Sequence: VPKNTSQTAA ITTKGGLVGL VDYPDDDEDD DEDEDKEDTL PLSKKAKFDS

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human SMEK1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for SMEK1

Target: SMEK1 (Serine/threonine-Protein Phosphatase 4 Regulatory Subunit 3A (SMEK1))

Alternative Name: SMEK1

Background: Regulatory subunit of serine/threonine-protein phosphatase 4. May regulate the activity of PPP4C at centrosomal microtubule organizing centers. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on 'Ser-140' (gamma-H2AFX) generated during DNA replication and required for DNA DSB repair.

Alias Symbols: smk1, FLFL1, PP4R3, SMEK1, smk-1, PP4R3A, MSTP033, KIAA2010

Protein Size: 833

Gene ID: 55671

NCBI Accession: NM_001284280, NP_001271209

UniProt: Q6IN85

Pathways: Regulation of Carbohydrate Metabolic Process