Hemoglobin, beta Adult Minor Chain (HBB-B2) (Middle Region) antibody

Catalog No. ABIN5673951

This Rabbit Polyclonal antibody specifically detects in WB. It exhibits reactivity toward Mouse.

Quick Overview for Hemoglobin, beta Adult Minor Chain (HBB-B2) (Middle Region) antibody (ABIN5673951)

Target: Hemoglobin, beta Adult Minor Chain (HBB-B2)

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: Western Blotting (WB)

Product Details

Binding Specificity: Middle Region

Sequence: SELHCDKLHV DPENFRLLGN AIVIVLGHHL GKDFTPAAQA AFQKVVAGVA

Purification: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of mouse HBB-B2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details

Target: Hemoglobin, beta Adult Minor Chain (HBB-B2)

Alternative Name: HBB-B2

Background: This gene encodes a beta polypeptide chain found in adult hemoglobin, which consists of a tetramer of two alpha chains and two beta chains, and which functions in the transport of oxygen to various peripheral tissues. This gene is one of a cluster of beta-hemoglobin genes that are distally regulated by a locus control region, and which are organized along the chromosome in the order of their developmental expression. In mouse, two major strain-specific haplotypes of the beta-globin gene cluster are found - a "single" haplotype found in C57BL/-type strains, which includes two highly similar adult beta-globin genes, beta s and beta t, and a "diffuse" haplotype found in strains such as BALB/c and 129Sv, which includes two somewhat diverse adult beta-globin genes, beta-major and beta-minor. This gene represents the beta-minor adult gene found in the "diffuse" haplotype. Primary chromosome 7 of the mouse reference genome assembly, which is derived from C57BL/6 strain mice, represents the "single" haplotype, while the "diffuse" haplotype is represented in the reference genome collection by the BALB/c strain alternate contig, NT_095534.1.

Alias Symbols: Hbb2, Hbbt2, beta2, AI036344

Protein Size: 147

Gene ID: 15130

NCBI Accession: NM_016956, NP_058652

UniProt: P02089