CHRM4 antibody (AA 131-230)

Catalog No. ABIN5675326

The Rabbit Polyclonal anti-CHRM4 antibody has been validated for WB and ELISA. It is suitable to detect CHRM4 in samples from Human.

Quick Overview for CHRM4 antibody (AA 131-230) (ABIN5675326)

Target: CHRM4 (Cholinergic Receptor, Muscarinic 4 (CHRM4))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CHRM4 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-CHRM4 Antibody

Binding Specificity: AA 131-230

Cross-Reactivity: Human

Predicted Reactivity: Mouse,Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CHRM4

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for CHRM4

Target: CHRM4 (Cholinergic Receptor, Muscarinic 4 (CHRM4))

Alternative Name: CHRM4

Background:

Synonyms: mAChR M4, Muscarinic Acetylcholine Receptor M4, Cholinergic receptor muscarinic 4, Chrm 4, CHRM4, HM 4, HM4, M4, Muscarinic acetylcholine receptor M4, ACM4_HUMAN.

Background: The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine to these receptors and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and postassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptor are unknown, however, mouse studies link its function to adenylyl cyclase inhibition. Muscarinic acetylcholine receptor M4 has been reported to be expressed in many regions of the rat brain, particularly the striatum and hippocampus.

Gene ID: 1132

UniProt: P08173

Pathways: cAMP Metabolic Process, Inositol Metabolic Process, Synaptic Membrane