EXD2 antibody (AA 351-621)

Catalog No. ABIN5675755

The Rabbit Polyclonal anti-EXD2 antibody is suitable to detect EXD2 in samples from Human, Mouse and Rat. It has been validated for WB, ELISA, IF (cc), IF (p), IHC (fro), IHC (p) and ICC.

Quick Overview for EXD2 antibody (AA 351-621) (ABIN5675755)

Target: EXD2 (Exonuclease 3'-5' Domain Containing 2 (EXD2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EXD2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)

Product Details anti-EXD2 Antibody

Binding Specificity: AA 351-621

Specificity: WB shows isoform 2

Cross-Reactivity: Human, Mouse, Rat

Predicted Reactivity: Dog,Cow,Sheep,Pig,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human EXD2

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for EXD2

Target: EXD2 (Exonuclease 3'-5' Domain Containing 2 (EXD2))

Alternative Name: EXD2

Background:

Synonyms: Exonuclease 3'-5' domain-containing protein 2, EXD2, C14orf114, EXDL2

Background: Exonuclease required for double-strand breaks resection and efficient homologous recombination. Plays a key role in controlling the initial steps of chromosomal break repair, it is recruited to chromatin in a damage-dependent manner and functionally interacts with the MRN complex to accelerate resection through its 3'-5' exonuclease activity, which efficiently processes double-stranded DNA substrates containing nicks.

Gene ID: 55218

UniProt: Q9NVH0