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TBC1D4 antibody (AA 574-712)

This anti-TBC1D4 antibody is a Mouse Monoclonal antibody detecting TBC1D4 in ELISA and FACS. Suitable for Human.
Catalog No. ABIN5684096

Quick Overview for TBC1D4 antibody (AA 574-712) (ABIN5684096)

Target

See all TBC1D4 Antibodies
TBC1D4 (TBC1 Domain Family, Member 4 (TBC1D4))

Reactivity

  • 55
  • 22
  • 14
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
Human

Host

  • 68
  • 2
  • 1
Mouse

Clonality

  • 66
  • 5
Monoclonal

Conjugate

  • 40
  • 4
  • 4
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
This TBC1D4 antibody is un-conjugated

Application

  • 35
  • 30
  • 17
  • 15
  • 13
  • 13
  • 11
  • 7
  • 6
  • 3
  • 3
  • 1
  • 1
  • 1
  • 1
ELISA, Flow Cytometry (FACS)

Clone

8A11A2
  • Binding Specificity

    • 15
    • 15
    • 8
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 574-712

    Purpose

    TBC1D4 Antibody

    Purification

    Purified antibody

    Immunogen

    Purified recombinant fragment of human TBC1D4 (AA: 574-712) expressed in E. Coli.

    Isotype

    IgG1
  • Application Notes

    ELISA: 1/10000

    FCM: 1/200 - 1/400

    Restrictions

    For Research Use only
  • Format

    Liquid

    Buffer

    Purified antibody in PBS with 0.05 % sodium azide.

    Preservative

    Sodium azide

    Precaution of Use

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Storage

    4 °C,-20 °C

    Storage Comment

    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
  • Target

    TBC1D4 (TBC1 Domain Family, Member 4 (TBC1D4))

    Alternative Name

    TBC1D4

    Background

    This gene is a member of the Tre-2/BUB2/CDC16 domain family. The protein encoded by this gene is a Rab-GTPase-activating protein, and contains two phopshotyrosine-binding domains (PTB1 and PTB2), a calmodulin-binding domain (CBD), a Rab-GTPase domain, and multiple AKT phosphomotifs. This protein is thought to play an important role in glucose homeostasis by regulating the insulin-dependent trafficking of the glucose transporter 4 (GLUT4), important for removing glucose from the bloodstream into skeletal muscle and fat tissues. Reduced expression of this gene results in an increase in GLUT4 levels at the plasma membrane, suggesting that this protein is important in intracellular retention of GLUT4 under basal conditions. When exposed to insulin, this protein is phosphorylated, dissociates from GLUT4 vesicles, resulting in increased GLUT4 at the cell surface, and enhanced glucose transport. Phosphorylation of this protein by AKT is required for proper translocation of GLUT4 to the cell surface. Individuals homozygous for a mutation in this gene are at higher risk for type 2 diabetes and have higher levels of circulating glucose and insulin levels after glucose ingestion. Alternative splicing results in multiple transcript variants encoding different isoforms.

    Molecular Weight

    146.5 kDa

    Gene ID

    9882

    UniProt

    O60343
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