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TBC1D4 antibody (AA 574-712)

TBC1D4 Reactivity: Human ELISA, WB, IHC, FACS, ICC, Neut Host: Mouse Monoclonal 3H4A4 unconjugated
Catalog No. ABIN5684096
  • Target See all TBC1D4 Antibodies
    TBC1D4 (TBC1 Domain Family, Member 4 (TBC1D4))
    Binding Specificity
    • 15
    • 14
    • 8
    • 8
    • 7
    • 7
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 574-712
    Reactivity
    • 70
    • 35
    • 27
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 82
    • 2
    • 1
    Mouse
    Clonality
    • 83
    • 2
    Monoclonal
    Conjugate
    • 36
    • 7
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This TBC1D4 antibody is un-conjugated
    Application
    • 36
    • 33
    • 15
    • 13
    • 13
    • 13
    • 11
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunocytochemistry (ICC), Neutralization (Neut)
    Purification
    purified
    Immunogen
    Purified recombinant fragment of human TBC1D4 (AA: 574-712) expressed in E. coli.
    Clone
    3H4A4
    Isotype
    IgG1
  • Application Notes
    ELISA: 1:10000, WB: 1:500 - 1:2000, ICC: N/A, FCM: 1:200 - 1:400, IHC: N/A
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified antibody in PBS with 0.05 % sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C/-20 °C
    Storage Comment
    4°C, -20°C for long term storage
  • Target
    TBC1D4 (TBC1 Domain Family, Member 4 (TBC1D4))
    Alternative Name
    TBC1D4 (TBC1D4 Products)
    Synonyms
    AS160 antibody, 5930406J04Rik antibody, A930035N22 antibody, AV295684 antibody, As160 antibody, RGD1561609 antibody, TBC1 domain family member 4 antibody, TBC1 domain family, member 4 antibody, TBC1D4 antibody, Tbc1d4 antibody
    Background

    Description: This gene is a member of the Tre-2/BUB2/CDC16 domain family. The protein encoded by this gene is a Rab-GTPase-activating protein, and contains two phopshotyrosine-binding domains (PTB1 and PTB2), a calmodulin-binding domain (CBD), a Rab-GTPase domain, and multiple AKT phosphomotifs. This protein is thought to play an important role in glucose homeostasis by regulating the insulin-dependent trafficking of the glucose transporter 4 (GLUT4), important for removing glucose from the bloodstream into skeletal muscle and fat tissues. Reduced expression of this gene results in an increase in GLUT4 levels at the plasma membrane, suggesting that this protein is important in intracellular retention of GLUT4 under basal conditions. When exposed to insulin, this protein is phosphorylated, dissociates from GLUT4 vesicles, resulting in increased GLUT4 at the cell surface, and enhanced glucose transport. Phosphorylation of this protein by AKT is required for proper translocation of GLUT4 to the cell surface. Individuals homozygous for a mutation in this gene are at higher risk for type 2 diabetes and have higher levels of circulating glucose and insulin levels after glucose ingestion. Alternative splicing results in multiple transcript variants encoding different isoforms.

    Aliases: AS160, NIDDM5

    Molecular Weight
    146.5 kDa
    Gene ID
    9882
    HGNC
    23495
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