Ancient Ubiquitous Protein 1 antibody (AA 229-410)

Catalog No. ABIN5684097

This Mouse Monoclonal antibody specifically detects Ancient Ubiquitous Protein 1 in WB and ELISA. It exhibits reactivity toward Human and Mouse.

Quick Overview for Ancient Ubiquitous Protein 1 antibody (AA 229-410) (ABIN5684097)

Target: Ancient Ubiquitous Protein 1 (Aup1)

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This Ancient Ubiquitous Protein 1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Clone: 1H6A1

Product Details anti-Ancient Ubiquitous Protein 1 Antibody

Binding Specificity: AA 229-410

Purpose: AUP1 Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human AUP1 (AA: 229-410) expressed in E. Coli.

Isotype: IgG2b

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Target Details for Ancient Ubiquitous Protein 1

Target: Ancient Ubiquitous Protein 1 (Aup1)

Alternative Name: AUP1

Background: The protein encoded this gene is involved in several pathways including quality control of misfolded proteins in the endoplasmic reticulum and lipid droplet accumulation. Lipid droplets are organelles in the cytoplasm that store neutral lipids such as cholesterol esters and trigylycerides to prevent the overabundance of free cholesterol and fatty acids in cells, but also to act as storage for other metabolic processes, such as membrane biogenesis. Reduced expression of this gene results in reduced lipid droplet clustering, a function that is dependent on ubiquitination of the protein. This protein contains multiple domains including a hydrophobic N-terminal domain, an acetyltranferase domain, a ubiquitin-binding CUE domain, and a UBE2B2-binding domain (G2BR). Alternative splicing results in multiple transcript variants.

Molecular Weight: 53 kDa

UniProt: Q9Y679