ARHGDIA antibody (Internal Region)

Catalog No. ABIN568700

The Goat Polyclonal anti-ARHGDIA antibody is suitable to detect ARHGDIA in samples from Human, Mouse, Rat, Dog and Cow. It has been validated for WB and EIA.

Quick Overview for ARHGDIA antibody (Internal Region) (ABIN568700)

Target: ARHGDIA (rho GDP Dissociation Inhibitor (GDI) alpha (ARHGDIA))

Reactivity: Human, Mouse, Rat, Dog, Cow

Host: Goat

Clonality: Polyclonal

Conjugate: This ARHGDIA antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-ARHGDIA Antibody

Binding Specificity: Internal Region

Sequence: C-QLAQIAAENE

Specificity: Recognizes ARHGDIA.

Cross-Reactivity (Details): Species reactivity (expected):Human, Dog, Cow.
Species reactivity (tested):Mouse, Rat.

Purification: Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide.

Immunogen: Peptide with sequencefrom the internal region of the protein sequence according to NP_004300.1. Genename: ARHGDIA

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for ARHGDIA

Target: ARHGDIA (rho GDP Dissociation Inhibitor (GDI) alpha (ARHGDIA))

Alternative Name: ARHGDIA / GDIA1

Background: Rho GDP-dissociation inhibitor 1, also known ARHGDIA, belong to the RAS gene superfamily encoding small guanine nucleotide exchange (GTP/GDP) factors. Localized to the cytoplasm, ARHGDIA inhibits the dissociation of GDP from Rho proteins, thereby preventing GTP from binding to and subsequently activating Rho proteins. In humans ARHGDIA can be phosphorylated at Ser 101 by p21-activated kinase, an event that inhibits ARHGDIA activity and may result in positive feedback regulation of certain ARHGDIA target proteins.Synonyms: Rho GDI 1, Rho GDP-dissociation inhibitor 1, Rho-GDI alpha, RhoGDI1

Gene ID: 396

NCBI Accession: NP_004300

UniProt: P52565

Pathways: Neurotrophin Signaling Pathway