THRA antibody (N-Term)

Catalog No. ABIN5688664

The Mouse Monoclonal anti-THRA antibody has been validated for WB. It is suitable to detect THRA in samples from Human, Mouse, Rat, Dog and Cow.

Quick Overview for THRA antibody (N-Term) (ABIN5688664)

Target: THRA (Thyroid Hormone Receptor, alpha (THRA))

Reactivity: Human, Mouse, Rat, Dog, Cow

Host: Mouse

Clonality: Monoclonal

Conjugate: This THRA antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 1330

Product Details anti-THRA Antibody

Binding Specificity: N-Term

Purification: Protein G purified

Immunogen: Peptide corresponding to amino acid residues from the N-terminal region of human thyroid hormone receptor, a2-isotype.

Isotype: IgG1

Application Details

Application Notes: The antibody has been directly tested for reactivity in Western blots with human tissue. It is anticipated that the antibody will react with bovine, canine, mouse and rat based on the fact that these species have 100 % homology with the amino acid sequence used as antigen.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 100 μLin 10 mM HEPES (  pH 7.5), 150 mM NaCl, 100 μg per mL BSA and 50 % glycerol.

Storage: -20 °C

Storage Comment: Thyroid Hormone Receptor antibody can be stored at -20°C and is stable at -20°C for at least 1 year.

Target Details for THRA

Target: THRA (Thyroid Hormone Receptor, alpha (THRA))

Alternative Name: Thyroid Hormone Receptor

Background: Thyroid hormones are essential for development of the central nervous system and deficits in these hormones during development affects such cognitive functions as learning and memory (Ambrogini et al., 2005, Chan and Kilby, 2000). Thyroid hormones exert their physiological role mainly through binding to specific nuclear receptors including the predominant isoforms of thyroid hormone receptors, TRalpha1, TRalpha2, TRbeta1 and TRbeta2. TRalpha1, TRbeta1 and TRbeta2 bind T3 with high affinity and also bind to thyroid hormone response elements (TREs) on chromatin to regulate the transcriptional processes in several target tissues, including adult rat brain (Constantinou et al., 2005).

Molecular Weight: 58 kDa

Gene ID: 7067

UniProt: P10827

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Sensory Perception of Sound, Cellular Response to Molecule of Bacterial Origin, Regulation of Lipid Metabolism by PPARalpha, Regulation of Muscle Cell Differentiation, Maintenance of Protein Location, Skeletal Muscle Fiber Development